Abstrakt

Cell Lines: An Invitro Model To Study Breast Cancer

Nida Jamil Khan

Breast cancer cell lines have been used widely to investigate breast cancer pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it is important to understand how well and which cell lines best model that diversity.Human breast tumor cell lines are needed for multidisciplinary research in breast cancer.In the laboratory breast cancer is often modelled using established cell lines. Utilization of cell lines as subtype systems in threedimensional and heterotypic cultures represent powerful approaches to investigate the signaling interactions that contribute to breast cancer biology. In the present review we discuss the use of breast cancer cell lines as experimental invitro models and put forward suggestions for improving their utility in translational breast cancer research