Cervical Pathologic Findings in Women with High Risk HPV Positive in Mashhad (North-East of Iran)

Masomeh Mottaghi, Mansoureh Mottaghi, Zahra Mottaghi, Zohreh Yousefi, Alireza Rezaee and Marjaneh Frazestanian

Introduction: To determine the number of occasional CIN2 and CIN3 in patients with high risk HPV(HRHPV) positive and relationship between HR HPV positive and normal cytology. Study was conducted to evaluate the pathologic findings in women with high risk HPV positive in Mashhad city. Material and methods: This descriptive cross-sectional study was performed on 325 women from 18-65 years old, who refer for cervical cancer screening from June 2015 to 2016 in an academic hospital of Medical Sciences of Mashhad. Both thin prep cytology and HPV testing by Cobas 4800 test was done for everyone. Then high risk HPV positive cases underwent colposcopy and cervical biopsy. Data were analysed by SPSS software (version18), Statistical tests Chi-square and t-test were used and P<0.05 was considered significant. Results: From total 325 women in 100 normal pap smear samples, HR HPV was positive in 20 cases (20%). In 47 patients with positive HR HPV, colposcopy and biopsy detect: normal pathology in 5 patients (11%), low grade squamous intraepithelial lesion (LSIL) in 39 patients (83%), and high grade squamous intraepithelial lesion (HSIL) in 3 of patients 6%. The most HR-HPV in 39 of patients with LSIL cases was other HPV 28 patients (72%). In 4 cases of HSIL 2 patients had positive HPV16 (50%) and one patient had positive HPV16 and HPV18 (25%), one patient with CIN3 had negative HRHPV. Based on use of HPV tests and colposcopy we could detect despite in HRHPV negative patients (325 samples) 3 cases of CIN2+ and one patient with had CIN3. Conclusion: The most common HPV type in Mashhad, Iran is other’s HR HPV but the most sever cellular dysplasia is seen in patients with positive HPV 16, 18. Vaccination with bivalent or Quadra valent is effective in prevention of cervical cancer.