Abstrakt

Design and In-Vitro Evaluation of Gliclazide Alginate Beads for Controlled Release.

TV Rao, N Bhadramma, I Immanuelu, M Radhika, and K Syamala

Microencapsulation by ionic gelation technique is an approach to achieve controlled release of drug, gliclazide beads were designed to improve the absorption and bioavailability of the drug. Gliclazide beads were formulated with sodium alginate and by combination of sodium alginate with hydrophilic polymer such as Na CMC in the ratio of (core:coat) 1:1,1:2, 1:3, 2:1 and 3:1 by ionic gelation method.The prepared beads were characterized such as particle size, angle of repose, compressibility index, hausner’s ratios, wall thickness, drug content,entrapment efficiency. The shape of beads were found to be spherical by SEM analysis. In-vitro dissolution data revealed that formulations exhibited the zero order kinetics and followed peppas transport mechanism.