Abstrakt

Evaluation of Cerebroprotective Effect of Flavonoid of Dalbergia Latifolia Against Cerebral Ischemia Re-Perfusion Induced Cerebral Infarction in Rats by BCCAO Method.

Sudhir C Kulkarni, Nagarathna PKM, N Sri Sainadh, and C Vasanthakumar

Dalbergialatifolia is commonly called as “Beete and sitsal”. In the present study the cerebroprotective effect of methanolic extract of bark of Dalbergialatifolia (DL) was carried out against the global model of ischemia in rats. The animals were pre-treated with DL for a period of 1week (500 mg/kg) p.o. The animals were anaesthetized with thiopentone sodium (45mg/kg) and infarction was induced by Bilateral Common Carotid Artery Occlusion (BCCAO) for 30 mins with the help of suture threads, the knots were released with the help of slip knots. The animals were allowed to re-perfuse for a period of 48 Hrs. Then the animals were sacrificed brain was decapitated. Biochemical estimations for SOD, CAT, MPO & MDA and histological examinations were carried out.