Abstrakt

Impact of Alcohol on Drug Metabolism and Alcohol - Drug Pharmacokinetic Interactions in Alcoholics

Srividya B

The review mainly discusses the impact of alcohol on the drug metabolism and alcohol-drug pharmacokinetic interactions. Many drugs can interact with alcohol, thereby altering the metabolism or effects of alcohol on the drugs. Drugs may affect the pharmacokinetics of alcohol by altering gastric emptying and inhibiting gastric alcohol dehydrogenase. Liquor can influence the pharmacokinetics of medications by adjusting gastric exhausting or liver digestion system (by inciting cytochrome P450 2E1). Medications may influence the pharmacokinetics of liquor by modifying gastric exhausting and restraining gastric liquor dehydrogenase. Alcohol can affect the pharmacokinetics of drugs by altering gastric emptying or liver metabolism. Many alcohol-drug interactions occur at the level of actual metabolism. Alcohol intake can alter the pharmacokinetics of medications, including their absorption and metabolism. Conversely, alcohol pharmacokinetics can also be altered by medications. Drugs may affect the pharmacokinetics of alcohol by altering gastric emptying and inhibiting gastric alcohol dehydrogenase. The mechanism of alcohol-medication interactions and Some Specific Interactions are discussed. INTRODUCTION