Isolation of Mangiferin from Flowering Buds of Mangifera indica L and its Evaluation of in vitro Antibacterial Activity

Taniya Biswas*, Argha Sen, Rini Roy, Sushomasri Maji, Himangshu Sekhar Maji

Mango (Mangifera indica L) which belongs to the family of Anacardiaceae, is a rich source of biologically active compound mangiferin, which is a natural xanthone C-glucoside. Mangiferin, (1,3,6,7-tetrahydroxy xanthone-C2-b-Dglucoside), has been isolated from various parts of Mangifera indica. Mangiferin is a pharmacologically active phytochemical present in large amount in bark, fruits, roots and leaves of Mangifera indica. Mangiferin has been traditionally used in some parts of world as anti-inflammatory, antibacterial, analgesic, antipyretic, antioxidant, antitumor, antiviral, immunomodulatory, anthelminthic and in obesity treatment. The present work is aimed to isolate mangiferin by column chromatography from the ethanolic extract of flowering buds of Mangifera indica L and assess its antibacterial activity. The conclusive structure of the isolated compound was established using TLC, HPLC, UV/VIS, FTIR and NMR spectral analysis. In vitro antibacterial activity of the isolated mangiferin was studied on Gram positive and Gram negative bacteria by agar disc-diffusion techniques. The solutions of the isolated mangiferin showed activity with regard to various strains of two bacterial species: Staphylococcus aureus (Gram positive) and Salmonella typhi (Gram negative). The present study confirms the antibacterial effect of the isolated mangiferin which could be further processed for its development as an antibacterial agent.

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