Abstrakt

Study of flow and interaction parameters of Aspirin in NS, DNS, RL, and pure water system at 298.15K, 303.15K, 308.15K, 310.15K and 313.15K

Arun B. Nikumbh, Ganesh K. Kulkarni and Ravindra C. Bhujba

The measurements of densities and viscosities of drug aspirin in pure water NS (Normal Saline), DNS (Dextrose with Normal Saline) and RL (Ringer lactate) systems have been made at 298.15K, 303.15K, 308.15K, 310.15K and 313.15K using a bi-capillary pycknometer and Ubbelohde viscometer. The density and viscosity data have been analyzed and used to explain the flow and molecular interaction parameters of drug aspirin in aqueous solutions as well as in presence of additives. Jones-Dole equation, Masson equation, Roots equation and Moulik equation have been verified at different temperatures. The drug interact with various ions, molecules, biological membranes present in the biological system is an important phenomenon and can be understood with the evaluated parameters.