Abstrakt

Effect of Alectra Parasitica Var. Chirakutensis on Aspirin Induced Ulceration in Rats

Ch V Rao, G Rajesh Kumar, Manju Sharma, Shyam Sundar Gupta and RLS Sikarwar

The effect of 50 % ethanolic extract of Alectra parasitica var. Chirakutensis was assessed in different acute gastric ulcer models in rats. Alectra parasitica administered orally at dose levels of 50 – 200 mg/kg, twice daily for 3 days showed dose dependent ulcer protective effect 48.89 – 82.22% protection on aspirin -induced acute ulcers. Besides, Alectra parasitica reduced the ulcer index with significant (P < 0.01 and <0.001) protection of lipid peroxidation and superoxide dismutase and increased in catalase activity, respectively. Preliminary phytochemical screening of the Alectra parasitica gave the positive test for steroids, alkaloids, terpenoids, saponins and tannins. The results indicate that Alectra parasitica possesses antiulcer activity