Abstrakt

Thyme Functionalized Polydopamine Coated ZnO Nanoparticles With Enhanced Antibacterial Activity For Biomedical Application

Parinaz Nezhad-Mokhtari1, Nahideh Asadi1, Yaeghob Sharifi2*, Morteza Milani3

Bacterial infections are a major cause of injury-related death, and several efforts have been developed to deal this problem. For this goal, we were synthetized a novel antibacterial agent based on thyme functionalized polydopamine coated ZnO NPs (TH-PDA@ZnNPs). Following the synthesis of ZnO NPs, a one-step, simple method was used to surface modification of PDA@ZnNPs with TH. The finding proved that creating NPs with a rod-shaped morphology created a large surface area for bacteria to contact. The formation of a homogeneous TH layer on the surface of NPs had no substantial effect on their shape. Antibacterial assays revealed that TH-PDA@ZnNPs had a much higher antibacterial activity against S. aureus and E. coli. This shows that PDA@ZnNPs and the TH grafted on the surface of PDA@ZnNPs have an excellent synergistic antibacterial effect. In conclusion, we suggest that the prepared TH-PDA@ZnNPs could be useful as antibacterial agents for biomedical uses.