Abstrakt

Comparative Study on Starch Citrate Vs Other Super Disintegrants in the Formulation Characteristics and In vitro Profile of Ondansetron Sublingual Tablets by Direct Compression

Newton AMJ, Bindu B and Archana C

Ondansetron sublingual tablets using various super disintegrants such as starch citrate, sodium starch glycolate, and croscarmellose sodium were prepared in this research work. For the first time, Starch citrate was tried as a super disintegrant. The formulation characteristics and various parameters of starch citrate based formulas were compared with other formulas to evaluate this profile as the super disintegrant. The study is focused on the rapid disintegration of the tablet in the oral cavity and masking the bitter taste of Ondansetron. Since Ondansetron bioavailability was 60% due to the first pass metabolism and it is suitable to convert it into the sublingual tablets which provide better bioavailability. The ingredients such as microcrystalline cellulose, mannitol, lactose, magnesium stearate and talc were also incorporated in the formulation design. The tablets were analysed for various quality control parameters and in vitro dissolution profile. The best formulation was subjected to stability studies and compared with marketed formulations. The drug release kinetics of formulation were studied by using the various pharmacokinetic models such as Zero Order, First order, Higuchi and Korsmeyer-Peppas kinetics.